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CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3
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DeCS
Descriptor
English
:
Cyclic Nucleotide Phosphodiesterases, Type 3
Descriptor
Spanish
:
Fosfodiesterasas de Nucleótidos Cíclicos Tipo 3
Descriptor
Portuguese
:
Nucleotídeo Cíclico Fosfodiesterase do Tipo 3
Tree Number:
D08.811.277.352.640.150.300
D12.644.360.008.300
D12.776.476.008.300
Definition
English
:
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of
CYCLIC GMP
to an allosteric domain found on the enzyme and through
phosphorylation
by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this
family
are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Entry Combination - descr/qualif
English
:
Cyclic Nucleotide Phosphodiesterases, Type 3
/
antagonists & inhibitors
use
Phosphodiesterase 3 Inhibitors
History Note
English
:
2008(1995)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52678
Unique Identifier:
D054684
Occurrence in VHL
:
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DeCS
CID-10
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